Neurologic complications in children under five years with sickle cell disease

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Neurologic complications of sickle cell disease in Africa

OBJECTIVE To summarize prevalence data on the neurologic complications of sickle cell disease (SCD) in Africa. METHODS We searched EMBASE, PubMed, and African Index Medicus to identify all relevant articles published from inception to May 31, 2016. Each study was reviewed for methodologic quality. A random-effects model was used to estimate the prevalence of neurologic complications of SCD ac...

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Five years of experience with hydroxyurea in children and young adults with sickle cell disease.

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Morbidity pattern in hospitalized under five children with sickle cell disease

BACKGROUND & OBJECTIVES Children with sickle cell disease require more frequent hospital care and younger children (<5 yr of age) are more vulnerable to mortality. There are limited data on the events leading to hospitalizations and death in younger children with sickle cell disease from India. This study was, therefore, undertaken to evaluate the morbidity pattern in hospitalized under five ch...

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Neurologic complications after allogeneic marrow transplantation for sickle cell anemia.

Seven of 21 patients with sickle cell anemia developed neurologic complications 5 to 243 days (median, 33 days) after allogeneic marrow transplantation. Among these 7 patients, indications for transplantation included either a past history of stroke (4 patients) or recurrent severe vaso-occlusive events (3 patients). All received marrow from an HLA-identical sibling after preparation with busul...

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ژورنال

عنوان ژورنال: Neuroscience Letters

سال: 2019

ISSN: 0304-3940

DOI: 10.1016/j.neulet.2019.04.030